Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol

Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol

A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.

CuCl2 Catalyzed Solvent-free One Pot Synthesis of Dihydropyrimidinones

One-Pot solvent-free synthesis of Highly Substituted Imidazoles catalyzed by zeolite

A series of tri- and tetra- substituted imidazoles were synthesized from benzyl, aldehyde and ammonium acetate in the presence of zeolite as an ecofriendly reusable catalyst under microwave irradiation in the absence of solvent. The yields are high to excellent and the use of microwave irradiation reduces reaction times to few minute.

one-pot solvent-free synthesis of highly substituted imidazoles catalyzed by zeolite

a series of tri- and tetra- substituted imidazoles were synthesized from benzyl, aldehyde and ammonium acetate in the presence of zeolite as an ecofriendly reusable catalyst under microwave irradiation in the absence of solvent. the yields are high to excellent and the use of microwave irradiation reduces reaction times to few minute.

Efficient Ce(NO3)3 x 6H2O-catalyzed solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones.

Cerium(III) nitrate hexahydrate efficiently catalyzes the three-component Biginelli reaction under solvent-free conditions of an aldehyde, a beta-keto ester or beta-diketone and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or -thiones in excellent yields.